Designer Babies: Are We Close?

Hashem Al-Ghaili www.youtube.com

Brief Summary

The video discusses the emergence of gene editing technology, specifically CRISPR-Cas9, and its potential to create "designer babies" by selecting desired traits and eliminating unwanted ones. It addresses the ethical implications, potential benefits like eradicating genetic diseases, and risks such as unforeseen side effects and the possibility of using the technology for non-therapeutic enhancements. The video highlights a Chinese scientist's claim of creating the first gene-edited babies and the controversy surrounding it, emphasizing that while the technology holds promise, it also raises significant concerns about the future of the human race.

  • Gene editing technology, CRISPR-Cas9, has made "designer babies" a potential reality.
  • Ethical implications include unforeseen side effects and the possibility of non-therapeutic enhancements.
  • A Chinese scientist claimed to have created the first gene-edited babies, sparking controversy.

Intro

The video starts by posing a hypothetical question about altering one's traits before birth, such as eye or hair color, or enhancing resistance to illnesses. It suggests that while this is not possible for current generations, gene editing may offer this possibility for future children. The presenter introduces the concept of "designer babies," made possible through gene editing, where desired traits can be selected and unwanted ones discarded. The video emphasizes that this future may be closer than many think.

The Dawn of Designer Babies

The video discusses the controversial claim by a Chinese scientist of creating the world's first gene-edited babies using CRISPR-Cas9 technology. It raises the question of whether this development should be embraced or met with concern. The technique allows for editing DNA, but there are fears that it could spiral out of control, leading to parents custom-ordering designer babies. The video questions how this might shape the future of humanity and at what cost.

CRISPR-Cas9 in Practice

The video explains that while it's not yet possible to order designer babies from a menu, the Chinese team used CRISPR-Cas9 to eliminate the CCR5 gene in human embryos. Disabling this gene would make the babies more resistant to HIV, cholera, and smallpox. The CCR5 gene codes for a protein that allows HIV to enter cells. The embryos were edited for seven couples affected by HIV, resulting in one successful pregnancy and the birth of twin girls. Couples could choose to use edited or unedited embryos. Eleven embryos were used in six attempts before the twin pregnancy was achieved. The technique could potentially prevent HIV transmission.

Ethical and Scientific Concerns

The video highlights the outcry in the scientific community following the claim, noting that there is no independent confirmation and the research has not been published in a journal. Bioethicists did not anticipate the widespread use of CRISPR-Cas9 in the near future, even for preventing genetic diseases, let alone for creating designer babies. Gene editing of this kind is banned in many countries, including the US and the UK, because the technology is still experimental. DNA changes can be passed to future generations, potentially with unforeseen side effects.

Potential Benefits and Risks

The video acknowledges that genetic modification techniques could eliminate devastating genetic disorders like Parkinson's disease and Down syndrome. It could help families where both parents carry genes that increase the risk of birth defects. Removing these genes could significantly lower the risk of genetically influenced birth defects and potentially remove these genes from the family tree over time. However, critics warn that interfering with the blueprints of life could lead to unintended genetic consequences worse than the diseases being cured.

Long-Term Implications

The video notes that CRISPR-Cas9 has been tried in adults to cure cancer and treat deadly diseases, but these changes are limited to one person. Prenatal genetic changes risk altering the genetics of a family tree forever. As the technology improves, it may be used for more than just disease prevention, potentially leading to non-therapeutic genetic enhancements like strength, beauty, gender, and intelligence. Humans tend to make the impossible possible, and we may have more control over human evolution than ever before.

Conclusion

The video concludes that genetic manipulation is no longer science fiction but a present reality. The future is uncertain, but gene editing is here to stay and will only become more sophisticated.

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Transcript

Full transcript of “Designer Babies: Are We Close?”. Click a timestamp to open the video at that moment. Need another video? Use the YouTube transcript generator.

0:09 [Music] if you could go back in time and change something about yourself before birth what would it be would you change your eye color or maybe the color of your hair perhaps you choose something a little less vain maybe you'd boost your resistance to certain illnesses for example well it's too late for any of us to do this but for our children there may be hope using gene editing we may soon be able to design the genes in our babies and select traits we want while discarding those we don't want the most exciting part this future may be closer than you think until recently designer babies were a

0:56 concept of science fiction something that was only possible in movies but now a Chinese scientist claimed that he has created the world's first Jean edited babies now that the dawn of designer babies is finally upon us should we panic or embrace it the gene editing technique CRISPR caste 9 has revolutionized humans ability to edit DNA but could we take things too far what if the embryo editing techniques spiral out of control allowing parents to custom order a designer baby how would this shape the future of the human race and at what cost only time will tell now it's a bit early

1:42 to consider ordering from designer baby menu cards to choose your baby's personality and traits in fertility clinics but the Chinese team used the CRISPR cast line gene editing technique to eliminate a single gene known as the ccr5 and human embryos for the first time disabling this gene would make the babies more resistant to HIV cholera and smallpox the ccr5 gene codes for a protein that allows HIV the AIDS causing virus to enter a cell according to the researchers embryos were edited for seven couples affected by HIV and one successful pregnancy led to the birth of twin girls from this treatment CRISPR cast nine gene editing was used to modify the embryos before they were implanted into the respective mother's

2:27 uterus couples could choose whether to use edited or unedited embryos for pregnancy attempts eleven embryos were used in six attempts before the twin pregnancy was achieved the technique could potentially prevent HIV from being passed on while the news is causing an outcry in the scientific community there is no independent confirmation of the claim and it has not been published in a journal yet about a year ago bioethicists did not see the widespread use of CRISPR cast line in the next two decades even for the Prevention of genetic diseases let alone for designer babies this kind of gene editing is banned in most countries including the US and the UK as the technology is still in experimental stages

3:13 the DNA changes can pass to future generations potentially with unforeseen side effects genetic modification techniques could lead to the elimination of devastating genetic disorders like Parkinson's disease and Down syndrome before a person is even born and could help families in which both parents carry genes that increase the risk of a birth defect the removal of these genes could significantly lower the risk of genetically influenced birth defects and could eventually lead to the removal of these genes from the entire family tree over time however critics warn that interfering with the blueprints of life to prenatally destroy diseases could lead to unintended genetic consequences that are even worse than whatever diseases were trying to cure CRISPR casts 9 has recently been tried in

3:58 adults as a possible way to cure cancer and treat deadly diseases but the difference is that these changes are limited to only one person by prenatally making genetic changes we take the risk of changing the genetics of a family tree forever and it's possible that has this technology improves it will be used for more than just disease prevention researchers suggests that even if we focus initially on improving health it could lead towards non-therapeutic genetic enhancement such as strength Beauty gender and intelligence humans have a tendency to make the impossible possible we know that human evolution hasn't stopped in fact as it turns out we may end up having more control of it now than ever before we have entered an

4:43 era where genetic manipulation is no longer a science fiction novelty it's a reality of the present we don't yet know what the future will look like but one thing is certain gene editing is here to stay and it's only going to get more sophisticated [Music]

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