0:00 Hi the third mechanism that plays a role in eh intracellular transport is transport that uses transport vesicles well this vesicular transport eh occurs when there is a protein that will be transferred from the endoplasmic reticulum to the Golgi body or from the Golgi body to the cell membrane Hi dedek lah the protein that is synthesized in the endoplasmic reticulum will be about Buds then alphas go to the Golgi body to be modified before
0:48 being secreted out of the cell well ah ah yes even this vesicular transport also occurs between parts of the Golgi body for example between sisgo lgi with amedia lgi and between the medial gorge with a trance Hi Nahl I hope she this vesicular transport is found for example in the process of exocytosis and endocytosis well exocytosis itself ah it can occur
1:35 constitutively meaning A3 is regulated but there is also exocytosis that occurs regulatively there are those who regulate there are those who command Well for Ah yes not positive for example ah that if it happens it can increase the surface area of the cell membrane so for example if there is there is something which will be transferred from the Golgi body to the family then it must be wrapped by a member Hai which was originally part of the Golgi body membrane Well
2:23 after the formation of the vesicles haqana move towards the cell membrane then fuse with the cell membrane and the membrane a & v sikula will increase the surface area of the cell membrane where it is Abdul Husein while the contents in the form of whatever protein or whatever are released this is constructive but the exocytosis which is regulative in nature there is someone who orders so for example the secretory vesicles are already in the cell it sprouts from the Golgi body but so that this can function with the
3:10 cell membrane to release its contents there is someone who orders there must be someone who orders that's why it's called wrestling yes this is the process of hormone secretion should be quiet whose orders are later there is a type of signal transduction that causes the vesicles that are already in the raw material containing protein and what is it to be released by way of av-sikou it's better docking on the cell membrane functions then releases its contents that's the account thief Hai Well so actually the exocytosis process takes
3:57 place constitutively so it's not regulated netim then functions to increase the area membrane surface but the cell membrane is its expansion is opposed by the endocytosis process endocytosis process hi hi Hi so later if there is a vesicle that buds from the lumen of the endoplasmic reticulum then a a Hi then goes to the membrane a.out Bro the target is antap in the form of an organelle between the
4:43 form of either a cell membrane later the vesicle containing this protein will move along the microtubule or microfilament using a motor protein as its carrier well this is more or less a section I'm sad ansan which shows the occurrence of the process of vesicle formation a in a certain part or when it was originally in the form of a curve like this then it became more and more curved Then rounded Then the circle facial is released from the membrane that forms Hi if you want this he makes Agam
5:32 west more or less like this so if you are a compartment that contains something it will be secreted then the red cargo molecule must first bind to its receptor the receptor is inserted into the membrane of the organelle where this synthesis will be later then after this cargo binds to its receptor later Then in the acito Solid cargo section it will be bound to one type of protein called clathrin through an intermediary protein intermediary which is partly there bkin so clathrin attaches to this receptor according to
6:21 using adapting as an intermediary molecule later if more Well later then the presence of this structure will cause the Aini membrane to be lifted to form a circle more and more accomplish Klaten adapting and this receptor is formed increasingly rounded Yes Well if it has reached its maximum circle later the base of this vesicle Aa which is built by which is wrapped by the Dynamite protein will twist will twist this part so that then the vesicle wrapped in the renin plate will be released from the
7:07 membrane that forms it Hi so that a powder like this is formed Well after it is released from here later Klaten the dynamic fund will release itself so that then it is formed eh formed Avicii sugar which is only abrasion of molecules along with its cargo Hi well Hi clathrina itself is a is a structure of a protein built by a-6a chain three heavy chains that are blood red heavy floor and three light chains
7:54 Well if he arranges himself later it will be similar to a basket that is similar to a basket later Brother if clathrina binds to vesicles that vesicles that will form a membrane will form vesicles later the function of clathrin for example helps so that The membrane that will form the vesicle is easy to detach from the membrane that forms it so if you want to simplify the stages there are several first cargo molecules will be inserted into which will he must bind to the receptor on the organelle membrane where it will
8:41 form later then the cytosolic part of this receptor will bind to clathrin which is assisted by the Amin protein so that then the membrane structure that is attached to the compression will be slightly lifted like this later if the more clathrin complexes eh dynamic and the cargo receptor protein are formed later it will become more rounded yes later when it reaches the maximum circle later the Dina Mini protein at the base of this vesicle will bring up this part so that then A is released
9:28 from the membrane where it forms the Apple process right PSI Mbak from the membrane to where it is formed it requires Energy that comes from hydrolysis gtp Hi Well after Adha is released later then the act latrine and its dynamics will detach from this vesicle so that this physical only contains the receptor protein a plus its cargo Hi later then the vesicle will be transported to its destination membrane between organelle membranes between
10:15 cell membranes using microtubules or microfilaments as bridges this is an example of the process Other More if this tdxone is endocytosis endocytosis for example in the process of low density lipoprotein entering the cell is the same as before requires a receptor of course the receptor is the LDL receptor because what is inserted is this LDR later the same as using clathrin Klaten which will make the iclay membrane part will bend inward then form a vesicle well this vesicle will later fuse with the early endosome
11:03 after functioning with the endosome later it will be transferred to the lysosome to be destroyed by hydrolytic enzymes contained in the lysosome then the LDL receptor returns to the organelle membrane where the membranes Syahrini the needs of the relevant cell membranes Hi this is me more incision the results when clathrin is about to be inserted into the cell this is formed a bend then the form of vesicles is released then later like this condition this Wow more or less so that the vesicle
11:51 reaches the membrane a-con partemen which is targeted then there is one type of molecule called Schneider then there are proteins that function to bring together Avicii skin that psychology is released from the cell compartment certain with the membrane Hi Ho the target compartment later there are two types there is a fishnet from the word vesicle snare there is atisna artist Netter is this Disney target later Afis
12:37 is in the vesicle that is formed then Tisna is inserted into the membrane of the target compartment later Afis hell Well meet with a designer who matches him so that later when the vesicle releases while carrying Tisna it will be efficient to look for Disney that complements with so that the contents so that this vesicle is not the wrong address well so fish advice in er this meets with its partner designer later then clathrin just releases itself so that later this vesicle can join
13:24 Hi the target membrane more or less like that So if there is that so later when there is a visionary adat isner on the target membrane it fits and binds then it will pull this vesicle docking on the target compartment membrane then it functions more or less like that yes This is this is the conclusion of the discussion about intracellular e-transport So if from the cytosol from Steve cytosol to the nucleus or
14:10 vice versa he is the one who uses the gate Earlier GT transfer but if from the cytosol to other organelles such as peroxisomes, plastic and endoplasmic reticulum methods, it uses Hai abroad entrance counters but if from between the endoplasmic reticulum, Golgi, endosomes, lysosomes and cell membranes, it uses vesicular transport
