Outperform CoQ10? Human Trials Reveal A Superior Mitochondrial Supplement

0:00 [Music] just kind of seeing some mitochondria facts. So I think you're all aware that the mitochondria are the powerhouse of our cells and so they make really basically all our energy. So 95% of the energy used by our body. But unfortunately, when you make energy in your mitochondria, they're also making these things called free radicals, which are these damaging molecules that occur when you take that oxygen that is allowing you to make, you know, the energy, the ATP, and you grab it from, you know, an oxygen molecule and stick it onto a water molecule, which is kind of what you're making energy from. You're taking oxygen,

0:46 turning it into water. um that oxygen can sometimes just get reactive and attack other things including your proteins, your DNA, your you know lipid membranes. So the sort of membranes around your cells super bad for you right so if you damage your DNA for instance you can imagine that that DNA is not going to be able to now replicate a new cell for you and you're not going to have as much growth and regeneration. If you damage a protein, that protein won't work anymore and, you know, your cells can dysfunction. So, if it's a skin cell, it's no longer going to make, you know, the nice kind of structure and texture your skin should have. So, you know, you can kind of imagine how this all works. Um, and so the mitochondria, because they're making so much of these free radicals, are actually exposed to

1:33 10 times more free radicals than the rest of the cell. So, it needs even more protection. But guess what? It's really actually hard to protect mitochondria because they're what's called a privileged area of the cell. So they have their own kind of membrane around them and it's really hard to get anything into that membrane because it's such a sort of delicate balance in the way it works. It's kind of protecting itself. So when people try to take, you know, lots of supplements or vitamins and things like that, a lot of it is not going to get into the mitochondria. So, you're not going to get all the benefits of, you know, antioxidants get kit that can help you with these free radicals. I think you guys all have heard of antioxidants before. There's only very, very few antioxidants that can really get into the mitochondria. Um, MoQ is

2:19 one of them, but I just want you to be aware of it. So because the mitochondria keep like making all these free radicals as they're making energy at some point damage starts to occur them and your actual energy production drops up to 10% per decade. So this is just how aging works. I think you guys have all seen this in action. You know as people are getting older they just have less energy. That's because your mitochondria aren't working well. If you get your mitochondria as protected as possible, then you're literally staving off an a an aging mechanism. So that's I I I think the main message I want you to just take home today is that if you can protect your mitochondria, you can actually decrease your rate of aging and keep your energy levels up, you know, to

3:05 as as optimal as you can. It's not perfect, but you know, it's it's definitely something that is possible with, as you guys have discussed, you know, the right kind of like multimodal healthy lifestyle, but also some supplements can help as well, too. And I want to just point out too that, you know, you will probably notice when you start to lose energy that you're noticing it in places like your brain, your heart, and your muscle because these are the areas that use the most energy. So, they wear out first, right? So, I think we can all sort of attest to that that a lot of the time our brain seems to wear out before other things are when you're having a lot of stress. Um, same thing with your muscles. And I don't know if you're all aware, your heart actually is the thing that usually wears out first. More people die of

3:52 heart disease than anything else. Okay. So, I just want to give you a quick analogy because I think this always helps explain a little bit more about this free radical thing. So, you know, imagine your cells are like cool plants. They're making energy, but they're also making pollution, which is that oxidative stress. So, they're just making all this stuff, you know, like bad damaging things that gets let out into the environment and then goes and attacks everything else nearby the way that air pollution can kind of attack all of us um when we're exposed to it. And what I think is interesting is that it's such a slow process, right? You just don't notice what's going on until it's too late, right? because you know when people actually start to really

4:37 notice the damage it's as I said you know probably decades later you know you haven't really seen sort of the damage occur in your body but it's happening and next thing you know you're you know diagnosed with things like diabetes fatty liver heart disease um the one thing that I can tell you is like the best way to keep your mitochondria healthy and you know prevent aging is something called calorie restriction. Has anyone heard about this before? So, if you are having, you know, kind of limited calories every day, and they've shown this in mice and pretty much every organism you can think of up to monkeys. They're still working on showing this conclusively in humans, but the idea is if you eat maybe like 6% of the calories

5:24 that you normally would, you decrease your rate of aging and you get to live longer. So that is what has like been shown for like decades and decades of research like yes yes yes this always works. No one can probably want to like think about a life where they're restricted all the time. It's too depressing. So there's been a lot of work trying to find what they call calorie restriction mimedics so they can mimic calorie restriction. And the reason why this is so helpful for your lifespan is that if you can trick your cells into thinking there's very little, you know, supply of energy in terms of like nutrients like calories coming in, then your energies like your your cells become more efficient in how they're using energy, right? They become more efficient. They're only making the

6:10 proteins you really need. They're only making, you know, extra cells that you really need. Because if you're making a ton of extra stuff, then you're actually producing things that, you know, then have to get some point cleared away and then that can cause wear and tear because you're just accumulating too much stuff. It's kind of like you can imagine, you know, when you're in your house and you've accumulated so much stuff and it's just gunking up your house. This is can this can also happen in your cells as well too. If you have too much energy, you can just gunk up your cells with too much stuff. And so what's interesting about this calorie restriction thing is that now that they found a few things that work on that things like um resveratrol. I don't know if anyone's ever heard about resveratrol. They found that they all seem to work on the same pathways which

6:55 are involving mitochondria and also involving these these I would say oxidative stress pathways. So if you can decrease oxidative stress right here it's I'm calling it reactive oxygen species. That's just another term for it. It's basically this this idea of you know these oxygenated molecules damaging you. Um you can prolong aging or not prolong aging prolong life through decreased aging. Um so Mito is actually working on those pathways. So that's what's kind of cool is that it really is you know I would say an energy maximizer but also an optimizer. Um, one other thing I just want to point out is that mitochondria are the thing that are making more oxidative stress than anywhere else in your body. But

7:42 there's a lot of oxidative stress coming from everywhere. And it's just a good thing to be aware of what can happen when you have these exposures to what I call endogenous oxidative stress. So, you know, mitochondrial disorders, um, metabolism, which I mean, you know, kind of being overweight or having like, you know, really high blood glucose, like diabetes or like too much inflammation or immune system going haywire. Like these all cause oxidative stress inside you, you know. So, endogenous factors. And then there's exogenous, which are things on the outside of your body that are also causing oxidative stress, like radiation, xenobiotics, or just literally like, you know, bacteria and things like that. smoking, alcohol abuse. So just you know minimizing

8:28 obviously oxidative stress from your mitochondria is good but then you know think of these other factors as well too. Um I'm just going to quickly try to talk about an antioxidant so you guys can understand like why something like mio is helpful getting rid of oxidative stress. And basically the main thing to remember is that um a reactive oxygen species is something that has an unpaired electron. It's got this electron that is really reactive. You know, kind of think of it is like, you know, like an electrical device that is just kind of like flowing with too much energy and it's just trying to do things, you know, like like to find a way to balance out its energy. That's what's going on here is that that unpaired electron is trying to find another electron to balance out its

9:13 energy. And so what an antioxidant does is it basically can donate an electron to this unbalanced free radical and then kind of calm it down so it doesn't want to damage anything anymore. So that's how antioxidants work. So that's how Mito works. It's basically got an extra electron that it can just sort of donate to things and then you know calm down that oxidative stress. So that is the secret. That's what Mito does. Um, why is Mito so different than all the other antioxidants I'm sure you've heard of. We all could have have heard about like, oh, you know, drink this berry juice. It's got lots of antioxidants. Mito is special because it's been engineered to be an antioxidant that gets into that mitochondria. Remember how I told you it's really hard to get things in the mitochondria? Mito was invented, I think

10:01 you probably have heard this, in New Zealand as a way to make a CoQ10 that can get into the mitochondria easily. And CoQ10 is what is called a natural antioxidant that your mitochondria make to protect itself. But as you get older, you make less and less CoQ10. And nobody knows quite why, but it's just simply something that it's been shown again and again. So, you know, this scientist, Mike Murphy, and this other scientist, uh, Rob Smith, we're trying to figure out what could we do about the fact that CoQ10 can't get into the mitochondria. Let's make this special molecule has a special tag on it that allows to get sucked into the mitochondria and act as an antioxidant and protect your

10:46 mitochondria better. So, that's how they made mito. And this is kind of how it looks, right? So, here's Mito Q and here's CoQ10. And the main part that's acting as antioxidant are these like little red dots right here. They're this they're the part that can give the electron, you know, donated to something else like a free radical. And then this part down here is this triphenol phosphonium ion. You don't have to remember that. It's not an important thing. Um, but the idea is it's very positively charged and the mitochondria is very negatively charged. So it basically gets sucked into the mitochondria is this positively charged thing that the mitochondria is trying to like you know sort of balance itself out. Nature is all about balance. It

11:33 really is. There's just a lot of it going on. So yeah, that is basically the beauty of Mitoq. It's this very special thing that get into the mitochondria better than anything else ever really. And there's studies that have been shown this you know in terms of other things like other kinds of antioxidant into mito mitochondria like mitoching mitochondria. So this is a picture of mitochondria against um a lot of damage from these free radicals which are these little sort of like sparky things right here. Um, it's preventing those free radicals from leaking into the water cell that damage, as I say, like your DNA and your proteins and all the rest. Protects against membrane damage. It

12:20 also upregulates um your natural antioxidants. So, that's also really important too to protect your your mitochondria, protects against DNA damage, and it supports clean energy production, which is that idea of like, you know, talking about the coal plant. If you can make energy with less air pollution, if you can make ATP, which is the energy currency of the cell, with less oxidative stress, then like you've won the game. So, so that's what it is. Are there any questions? I know I talk fast and sometimes I get excited and I try to like get a little bit too fancy with with the analogies, but I hope it's clear. Yeah. And just FYI, um I have put people on mute or everybody on mute. So if you do have a question any point just remember to unmute yourself.

13:07 Ah okay. Yeah. Yeah. Definitely put you on mute and Okay. Um this slide is just something that I've had so many people ask me about the differences of CoQ10 and Mito that I just feel like it's good to have this slide to just really point out how it's different from CoQ10 because I'm sure you've all have heard of CoQ10. Um, but the the main thing is CoQ10 is a great antioxidant on its own. It's just doesn't really get into many places. It's absorbed really badly into the body in general. You know, you have to take a fatty foods to have any kind of hope of getting it absorbed. Um, but even then when you take it, it kind of very slowly gets taken up into like organs and

13:53 tissue and it really doesn't go into the mitochondria at all, like barely any of it. So, you need to take tons of it. Um, and this is this is also I think where you know when people try to take Mito like they're always probably you know fighting against the fact that most of it's just getting like flushed out of your body right away. I just want to also point out this study about Mito versus CoQ10. This is the one study that we actually looked at trying to understand how Mito is working differently than CoQ10. And you know mainly what we showed in this study is we gave Mito 20 mugs a day or 6 weeks to middle-aged men. Um and then also gave another group of men CoQ10 in the form of cunol is like a really popular brand of CoQ10. And what we saw was that for

14:42 muscle mitochondria reactive oxygen species the mitoq dose decreased those reactive oxygen species. This is called hydrogen peroxide. This is a really particularly bad form of reactive oxygen species. But uh CoQ10 did not do anything really. It was not significantly changing your free radicals. So that's kind of I would say our proof that we saw that you know CoQ10 is really not getting to the mitochondria where it needs to be in your muscles at least. Um but Mito is. And then we also looked at a few other things in the muscle like these uh antioxidant enzymes that are also really important for protecting your mitochondria. And we saw interestingly that mito could increase catalase which is a really I would say key antioxidant

15:28 enzyme and CoQ10 wasn't really doing anything at all. So that's just kind of you know because people are always saying like prove that it's different than CoQ10. This is what I would say is our proof. Um so I am now going to go into clinical studies but I will tell you we have so many clinical studies that I cannot tell you all of them. We have about 24 that have been completed another 30 or so in the pipeline. Hundreds of millions of dollars have been spent on Mitoq. So, you know, we have a lot of data that like literally if you want to know if Mito can affect XYZ, I could probably find you some study that that indicates of whether it can or not. Um, so just let me know if you've got like any particular question on what it can do.

16:14 This one I did want to go into because I I think this is a really pivotal study of um Mito for vascular function which is I think some something that I I don't know if people are always thinking about their heart as much as they should. I mean mostly you know we live our life feeling pretty healthy and all the rest but as I said at the very beginning most of us will die of some sort of heart related dysfunction. Um, you know, there's cancer, there's other things, but this is really the thing that will probably kill the majority of us. You know, stroke or, you know, other types of things that are affecting our heart. Um, and one of the best ways you can actually even understand if you're aging or not is your arteries start to harden. This is a classic sign of aging. And

17:01 very few things can stop your arteries from hardering hardening which is is a big deal because if you can't keep your arteries flexible, you can't keep blood flow optimal to all your organs. And this is going to affect your brain function. This is going to affect your muscles. This is going to affect how much you can regenerate because yeah, you need all that blood, those nutrients getting to everywhere at the right amounts. And so, you know, this this blood flow thing is super important. Um and what they saw with Mitoq is that after six weeks of Mitoq given to people who are you know somewhat older 60 to 79 uh years that they were able to show that vasod deletion was improved by 42% um with mitoq and it also decreased this

17:47 really important type of cholesterol called oxidized LDL. I think you've all heard of LDL cholesterol is like the bad cholesterol but actually why is it bad? It's bad because it's very easily oxidized. So, it gets attacked by those free radicals. Once it gets attacked by those free radicals, it then starts to damage your arteries. It makes a scar on your arteries. Once you have a scar in your arteries, that scar can start to be filled with plaque and that is how you get clogged arteries. So, that's actually why people have heart attacks is this clogging of arteries. And so this is where oxidized LDL was like a really really bad um biioarker for your overall aging and heart health. Um and

18:33 Mito is also able to decrease that as well too. And lastly as I said you know this aortic or artery stiffening artery hardening was also reduced by mito. So this is I think you know across the board all these different indications of how good you know Mito is for your vascule for your heart for your arteries and the way that your blood can then keep you healthy as well. Now I'm going to switch over to another pivotal study which is on exercise because for sure you know without a doubt I'm sure you've heard this before exercise is the very best thing you can do for your health. And what I always hear is people saying like, "Oh, but you know, I just I just don't feel like it. I don't feel very good. You know, it's

19:19 really hard for me." And so I always like to point out that something like mio can make it so exercise can go better for you, right? So it's that little boost. And so for instance, um, in this particular area, like they tried to show whether, you know, people who are middle-aged, you know, that maybe have not exercised a ton in their lives. if you try to see how well they can do a very very like difficult thing which is a time trial. I don't know if you guys have heard of time trials what they are. It's basically when you have to like bike as fast as you can until you feel like you're going to explode. You're going to just die. It's really hard. Um they were like, "Okay, let's see if Mito can make it so that that's an easier thing." And what they did show is that they can make it actually an easier

20:04 thing. So, you know, they could complete this really hard time trial faster. they had better energy output and when they completed that really really stressful, you know, exercise that they had less of these isoprostates which are a really important marker of inflammation. And inflammation is basically, you know, when you you've made your muscles really unhappy and and somewhat damaged and they're no longer going to be working as well and you have to then wait for them to recover. Well, now this is making it so if you take Mito, your muscles can recover quicker because they're having less inflammation. So, yeah. So, I think this is another nice thing to just also recognize about something like Mito. It's helping your muscles work as well. And this one I think is a very perfect example of how

20:52 you can take exercise, which as I said, you know, so good for your health and mito and see that they are of synergistic effects. So this is where uh they took once again um male subjects still works for women. I can also show you some women's studies as well who are a little bit older and hypertensive and they gave six weeks of Mitoq 20 milligrams again with or without moderate exercise. So like this exercise regime and they saw that um with Mitoq just alone you could improve their blood pressure and you could also improve these oxidative stress markers like um MDA. MD is another one that kind of causes inflammation and you know sort of wear and tear in your muscles and they they saw that you know exercise could do a good job too but when you combine them

21:40 together it was like even more powerful so there's like this nice synergy so I think this is really important because sometimes people are sort of saying you know like what's the point of of like you know exercise if it's really hard for me you know is it going to be like a big benefit well Mito can help that benefit it and it'll also synergize so you're getting more out of it. And so I will say, you know, what I was really delighted to see actually last week was another study on exercise, but this time with people with multiple scerosis. And what they were trying to show here is not so much whether they can actually stave off multiple scerosis because those kinds of studies are really really long and like very involved. What they're trying to do here

22:26 is do a pilot study. So you know just that they had the hypothesis that maybe Mitoq can help with multiple scerosis. So let's first look at some biomarkers that might indicate that it will be good and beneficial in the long run for multiple scerosis symptoms. So that's what they are trying to do in this study. So they basically just gave for eight weeks. So, you know, not enough time to make a huge difference in function, but enough difference to start to see whether, you know, these biomarkers that are very indicative of, you know, multiple scerosis dysfunction can be changed. And then they're also interested to see how exercise can also, you know, have an effect on these kind of inflammatory markers. And so they paired Mito with exercise. This is just to give you an idea of what the exercise

23:13 was. It's not a crazy amount of exercise. is basically 5 minutes of warm-up, 20 minutes of exercise training at around, you know, 50% of your maximum heart rate and then a 5 minute cool down. So, not really crazy. And then they looked at um these inflammation markers like isle six. And what I thought was really interesting is they looked at both premenopausal and menopausal women because I am sure you guys have all heard that once you go through menopause, you know, this protective estrogen goes down. You know, it kind of drops to almost like male level and you start getting a lot more of these I would say kind of diseases of aging like I mentioned like heart disease, you get like more diabetes.

24:00 You've probably all heard, you know, after menopause, you're just accumulating a lot more fat and you're having a lot more inflammation. And so you can see here that during menopause, you actually are just having a lot more inflammation in general. It's just it's just happening. Um, so Mito is maybe not doing as much of an effect, but it still is having a synergy with exercise, which I think once again is very cool. But with premenopause, you can see that Mito is having a really strong effect as is exercise. So I think what I would just venture to say here is that it's really clear that before menopause it's really important to exercise and also you know protect your mitochondria and keep all this um going as well as you can because it'll be a lot more difficult after you

24:46 go through menopause. Um, but I will say interestingly, this is a little bit of a side, uh, there's now a whole field, believe it or not, of looking at ways to stave off menopause is a way to stave off biological aging, which I think is such a fascinating area. So, there's a lot of data out there that shows if you have menopause at a much later age, this is also going to be predictive of you having a longer and healthier lifespan, which, you know, is is sort of cool. So keep your your ovaries healthy and keep your uh yourself healthy and you will probably also have those effects as well. Um I am probably just going to really lightly touch on this one because this

25:32 is another study that just came out I think actually literally maybe like three days ago where they're trying to see if Mito can have an effect for diabetes. And I thought this was really cool because they were like, how do you show like the very first sort of like start of diabetes? You know, what is the damage that's happening that brings about diabetes? And what diabetes really seems to be is like this this inflammation and oxidative stress that's occurring, especially in the mitochondria, that's brought about by too much sugar and fat in your bloodstream. So they mimicked too much sugar and fat in your bloodstream by having people take what's called a bolus lipid challenge. So basically they made people take like a huge amount of fat

26:19 all at once. It's like having like a huge pizza or something like that um to see what kind of stress this would cause on your body. And what they saw was just this one lipid challenge basically made you a little bit diabetic like right away. So it made you insulin insensitive. Then they took Mito and wanted to explore whether this could, you know, keep your insulin sensitive still. So you could still have, you know, this ability to take in this glucose, you know, and these lipids that you just took on in a more kind of appropriate fashion and decrease oxidative stress as well. And what they saw was that Mito actually could. So it made it so that you know your insulin was like more

27:04 robust and it also made these glute 4 transfers which are allowing glucose to be taken up in your muscle cells more active. So you're getting rid of that glucose so it's not just sitting around in your blood causing oxidative stress and inflammation. It's inside your muscles where it can like then now be used as energy. So, I thought this is really cool, you know, kind of the very first start of how diabetes is caused. You know, Mito might be a way to just keep that from happening. Um, early days, but I thought it was I thought it was really encouraging. So, I wanted to share that with you. Um, lastly, I So, I've been showing you all these clinical studies, but this is another one that I'm just really fond of

27:49 because I'm a brain scientist. I wanted to talk a lot more about the brain than I usually can because I have to really focus on the heart. That's where monito is working best. But I thought this is really fascinating um as an animal study because they were trying to see um how air pollution causes you know brain dysfunction and I don't know if you're aware for instance that if you live for instance like like less than a mile away from major highway you will have higher risk of getting Alzheimer's right. So all that that pollution that oxidative stress from like air pollution can affect your brain function over time. Um so you know obviously you can't test on humans like let's like give them lots of air pollution and see what happens. Um, so what they use here is a mouse study where they exposed mice to these carbon

28:35 particulates which are very similar to like what you find in car pollution or wildfires and saw that um when they're giving mitoching water for these mice, it helped the mice stayed not only more cognitively healthy, um, it also improved their mood. Believe it or not, you can actually measure mood in mice. I've done this many times myself. um kind of interesting but you know they also saw too of obviously your lung function was better um and this is all to do with keeping your mitochondria happy so they were also measuring the mitochondria in your brain and your lungs and saw that these are all functioning much better with mitoq so I thought this was interesting just because you know especially in the US you're probably aware we're having wildfires all the time and places like China where we saw

29:22 a lot of mitoq there's a lot of air pollution so um yeah so it's it's another way to protect yourself. Uh, so I'm now wrapping up. I didn't want to like make you have to like listen to me forever, but the main thing I wanted to let you know of is some studies that are kind of interesting for you. Um, we have one on fatigue and multiple scerosis, which is literally just finishing up right now. So, we're really excited to see how that looks. As soon as we have data on it, I am happy to share that with you. So, any any moment now. Um we have a whole bunch on other kinds of brain disease which I think is really fascinating. We have it on schizophrenia on something that we call frailty. Frailty is basically when you get you know really kind of like have difficulty

30:09 being mobile and you have difficulty walking and this usually comes handinhand with also cognitive dysfunction that can lead to Alzheimer's. So we're looking basically at whether Mitoq can stave off Alzheimer's and also this you know kind of mobility issue. Um we also have a lot of neurovvascular function studies. So you know once again seeing if you can kind of keep that blood flow to the brain better for better cognition. Um and also a recent one that's so recent I haven't actually put it on this list in ALS. So that's another one that we're really excited about. Taking a while to have that one get done. It'll probably be a couple years but um yeah. So, just wanted to let you know some of the studies that we're we're trying to look at. We even have one in COVID, believe it or not, though doesn't seem like anyone's getting COVID these days. Um,

30:54 but we definitely hear of long COVID and we we think long CO is actually another thing can help with [Music] [Applause] [Music]